A great gaming mouse with side buttons can speed up abilities, macros, and everyday commands without forcing your left hand to do all the work.
Whether you play MMO, MOBA, or just want extra controls for productivity, the right model comes down to button layout, sensor quality, grip comfort, and connection type.
Best 10 Gaming Mouse with Side Buttons Picks for 2026
MMO Control Pick
Redragon Wireless 16-Button MMO Mouse
- 12 side buttons for fast macro access
- 16 programmable buttons with 5 profiles
- Wireless rechargeable design with RGB lighting
Best For: MMO and MOBA players who want maximum button mapping
Long-Life Wireless Pick
Razer Basilisk V3 X HyperSpeed
- 9 programmable controls in an ergonomic shape
- HyperSpeed wireless and Bluetooth support
- Up to 285 hours of battery life
Best For: Gamers who want a comfortable wireless mouse with balanced buttons
Budget MMO Workhorse
UtechSmart Venus Wired MMO Mouse
- 12 side buttons for MMO macro mapping
- Adjustable weight and 16,400 DPI
- Wired design with RGB lighting
Best For: MMO players who want a wired, highly customizable mouse
Premium MMO Pick
- 19 programmable buttons for MMO macros
- HyperSpeed wireless and Bluetooth support
- Focus Pro 30K sensor with HyperScroll
Best For: MMO gamers who want a high-button-count wireless mouse
MMO Macro Specialist
Corsair Scimitar RGB Elite Wired MMO Gaming Mouse
- 12 repositionable side buttons
- 17 programmable buttons total
- 18,000 DPI wired optical sensor
Best For: MMO and MOBA players who want maximum side-button control
Simple Ergonomic Pick
Razer DeathAdder Essential Wired Gaming Mouse
- 5 programmable buttons
- Ergonomic right-handed grip
- 6,400 DPI optical sensor
Best For: Players who want a comfortable mouse with a few side buttons
Wireless Button Powerhouse
Corsair Scimitar Elite Wireless SE MMO Mouse
- 16 programmable buttons
- Adjustable side-button layout
- Up to 150-hour battery life
Best For: MMO players and streamers who want wireless side-button control
Ergonomic Precision Pick
Razer Basilisk V3 Customizable RGB Wired Mouse
- 11 programmable buttons for macros and extra controls
- Ergonomic right-handed shape with thumb rest
- 26K DPI sensor and HyperScroll tilt wheel
Best For: Players who want a wired ergonomic mouse with lots of programmable inputs
MMO Wireless Heavyweight
ASUS ROG Spatha X Wireless Gaming Mouse
- 12 programmable buttons with 6 side buttons
- Dual-mode 2.4GHz wireless and USB-C wired
- 19K DPI sensor with magnetic charging dock
Best For: MMO and MOBA players who want lots of side controls and wireless flexibility
Value MMO Side-Key Pick
LTC MKM071 Tri-Mode Wireless MMO Mouse
- 11 programmable buttons with 7 side buttons
- Tri-mode 2.4G, Bluetooth, and wired connectivity
- RGB charging dock with rechargeable battery
Best For: MMO and MOBA players who want many side buttons and flexible connectivity
MMO Control Pick – Redragon Wireless 16-Button MMO Mouse
If you want a gaming mouse with side buttons that leans hard into MMO-style customization, this Redragon model is built for complex key mapping. With 12 side buttons, 16 programmable buttons total, and wireless operation, it’s aimed at players who want lots of commands close to the thumb without giving up flexibility for daily PC use.
Best For: MMO and MOBA players who want maximum button mapping in a wireless mouse.
Pros:
- 16 programmable buttons with macro editing and 5 memory profiles
- 12 remappable side buttons for fast access to in-game commands
- Wireless design with rechargeable battery and wired charging support
- Adjustable DPI up to 16,000 and polling rate up to 1000Hz
Cons:
- Designed primarily for right-handed users
- RGB off is needed to reach the quoted 70-hour standby time
Overall, this is a strong choice if your priority is sheer button count and macro flexibility. It’s less about minimalist design and more about putting MMO controls where your thumb can reach them quickly.
Long-Life Wireless Pick – Razer Basilisk V3 X HyperSpeed
This gaming mouse with side buttons is a good fit if you want a more streamlined control layout without giving up customization. The Basilisk V3 X HyperSpeed offers 9 programmable controls, an ergonomic shape, and dual wireless options, making it practical for players who split time between gaming and everyday computer use.
Best For: Gamers who want a comfortable wireless mouse with a balanced number of programmable buttons.
Pros:
- 9 customizable controls for macros and shortcuts
- HyperSpeed wireless plus Bluetooth connectivity
- Very long battery life, up to 285 hours on HyperSpeed Wireless
- 18K optical sensor and Gen-2 mechanical switches
Cons:
- Fewer controls than MMO-focused mice
- Uses a single AA battery instead of a built-in rechargeable battery
In practice, this mouse makes sense if you want side-button utility but not a crowded MMO layout. It favors comfort, endurance, and reliable wireless performance over maximum button count.
Budget MMO Workhorse – UtechSmart Venus Wired MMO Mouse
If you’re shopping for a gaming mouse with side buttons and want a wired MMO layout, the UtechSmart Venus is built around heavy customization. It combines 12 side buttons, adjustable weight, and an ergonomic right-handed shape, making it a practical pick for players who want lots of thumb-accessible inputs at a lower-frills price point.
Best For: MMO players who want a wired, highly customizable mouse with many side buttons.
Pros:
- 12 side buttons that can be mapped to macros and keyboard combinations
- Adjustable DPI up to 16,400 with on-mouse sensitivity control
- Adjustable weight system for more tailored feel
- RGB lighting with multiple profiles and color modes
Cons:
- Wired-only design
- Right-handed shape limits universal use
This is a feature-packed MMO mouse if you want a lot of buttons and direct control without depending on wireless battery life. It stands out most when macro-heavy gameplay and thumb-button access matter more than a lightweight, minimalist design.
Premium MMO Pick – Razer Naga V2 HyperSpeed
For buyers looking specifically for a gaming mouse with side buttons, the Razer Naga V2 HyperSpeed is built for serious MMO control. It features 19 programmable buttons, HyperScroll technology, and a Focus Pro 30K optical sensor, so it’s aimed at players who want a dense command layout with premium wireless performance.
Best For: MMO gamers who want a high-button-count wireless mouse with premium sensor and scroll features.
Pros:
- 19 programmable buttons for advanced macros and game commands
- HyperSpeed wireless plus Bluetooth connectivity
- Focus Pro 30K optical sensor for precise tracking
- Up to 400 hours of battery life on Bluetooth
Cons:
- Large control layout is best suited to MMO-style games
- Uses a replaceable AA battery rather than built-in charging
This mouse is the most feature-dense option in the group for command-heavy play. If you want many side buttons and advanced scrolling in one wireless package, it delivers a very capable setup.
MMO Macro Specialist – Corsair Scimitar RGB Elite Wired MMO Gaming Mouse
If you want a gaming mouse with side buttons built for dense MMO and MOBA keybinds, the Corsair Scimitar RGB Elite is aimed squarely at that job. Its standout feature is the 12-button side array, which can be repositioned with the patented Key Slider system to better match your grip and thumb reach. With 17 programmable buttons total, an 18,000 DPI optical sensor, and a contoured shape, it prioritizes control and customization over simplicity.
Best For: MMO and MOBA players who want a highly programmable wired mouse with adjustable side-button placement.
Pros:
- 12 repositionable side buttons plus 17 programmable buttons total
- 18,000 DPI optical sensor with 1 DPI adjustment steps
- Durable build with 50 million click-rated Omron switches and braided cable
- Contoured right-handed shape with a supportive finger rest
Cons:
- Wired USB connection only
- Right-handed design limits ambidextrous use
- Side-button layout may be more than casual players need
This is a strong pick if your main priority is packing more commands onto your mouse without losing comfort. The adjustable side-button rail is the key differentiator, making it easier to adapt the mouse to different grip styles and hand sizes.
Simple Ergonomic Pick – Razer DeathAdder Essential Wired Gaming Mouse
For shoppers comparing a gaming mouse with side buttons but not needing a crowded layout, the Razer DeathAdder Essential keeps things straightforward. It offers 5 programmable buttons, a 6,400 DPI optical sensor, and an ergonomic right-handed shape with rubber side grips for added control. This is a practical option if you want a familiar gaming-mouse feel without moving into MMO-grade button counts.
Best For: Players who want a comfortable wired gaming mouse with a few programmable side buttons and an easygoing layout.
Pros:
- 5 programmable buttons for remapping and macro functions
- Ergonomic right-handed design with rubber side grips
- 6,400 DPI optical sensor with on-the-fly sensitivity adjustment
- Mechanical switches rated for up to 10 million clicks
Cons:
- Far fewer buttons than MMO-focused mice
- Wired-only design
- Lower DPI ceiling than higher-end gaming mice
This mouse makes sense if you value comfort and a clean button layout more than extreme customization. It gives you the side-button basics and dependable performance without overwhelming the hand or the desk.
Wireless Button Powerhouse – Corsair Scimitar Elite Wireless SE MMO Mouse
If you need a gaming mouse with side buttons and prefer wireless freedom, the Corsair Scimitar Elite Wireless SE brings a lot to the table. It includes 16 programmable buttons, a 33,000 DPI MARKSMAN S optical sensor, and Key Slider side-button adjustment, plus Elgato Stream Deck integration for extra workflow flexibility. With SLIPSTREAM wireless, Bluetooth, and USB options, it is built for players who want high customization without being tied to a cable.
Best For: MMO players, streamers, and multi-profile users who want a wireless high-button-count mouse.
Pros:
- 16 programmable buttons for broad control and macro use
- Key Slider system to adjust side-button placement
- 33,000 DPI sensor with 1,000Hz polling on SLIPSTREAM wireless
- Up to 150-hour battery life with wireless, Bluetooth, and USB options
Cons:
- Battery-powered design adds charging management
- Right-handed shape only
- Feature set may be overkill for simple gaming needs
This is the most feature-rich option here if your priority is button density and wireless convenience. The side-button flexibility and Elgato integration make it especially appealing for players who also stream or manage complex profiles.
Ergonomic Precision Pick – Razer Basilisk V3 Customizable RGB Wired Mouse
If you want a gaming mouse with side buttons that feels quick to reach and easy to control, the Razer Basilisk V3 is built around that idea. It pairs an ergonomic right-handed shape with 11 programmable buttons, a 26K DPI optical sensor, and a HyperScroll tilt wheel for games that need fast inputs and flexible scrolling.
Best For: Players who want a wired ergonomic mouse with plenty of programmable inputs and a thumb-rest shape.
Pros:
- 11 programmable buttons give you plenty of side and top controls for macros and actions.
- Ergonomic design with thumb rest supports quick access and a comfortable grip.
- 26K DPI sensor and optical switches aim for fast, precise performance.
- HyperScroll tilt wheel adds speed for scrolling or a more tactile mode for weapon and skill cycling.
Cons:
- It is wired, so it is not the best fit if you want wireless freedom.
- Right-handed shape limits comfort for left-handed players.
Overall, this is a strong pick if you want a feature-rich gaming mouse with side buttons and a comfortable ergonomic layout. It leans toward responsiveness and customization rather than minimalism.
MMO Wireless Heavyweight – ASUS ROG Spatha X Wireless Gaming Mouse
The ASUS ROG Spatha X is a gaming mouse with side buttons designed for MMO and MOBA players who want a large, heavily featured layout. It offers 12 programmable buttons, including 6 strategically placed side buttons, plus dual-mode connectivity so you can game wirelessly or stay plugged in over USB-C.
Best For: MMO and MOBA players who want lots of side controls, a large shape, and wireless or wired play.
Pros:
- 12 programmable buttons include 6 strategically positioned side buttons for macros and game actions.
- Dual-mode connectivity supports low-latency 2.4GHz wireless or USB-C wired use.
- 19,000 DPI optical sensor and 1000 Hz polling rate are aimed at accurate tracking.
- Up to 67 hours of battery life and a magnetic charging dock add convenience.
Cons:
- At 168g, it is a relatively heavy mouse.
- Large right-handed design may feel bulky if you prefer compact mice.
If you want maximum side-button access and a feature-packed MMO shape, the Spatha X stands out. It is more specialized and substantial than a general-purpose gaming mouse, but that is exactly the appeal here.
Value MMO Side-Key Pick – LTC MKM071 Tri-Mode Wireless MMO Mouse
If you are looking for a gaming mouse with side buttons for MMO-style shortcuts, the LTC MKM071 is built around control and flexibility. It includes 11 programmable buttons with 7 side buttons, tri-mode connectivity, and a PAW3311 sensor that reaches up to 12,000 DPI for everyday gaming and productivity use.
Best For: MMO and MOBA players who want many side buttons, tri-mode connectivity, and a charging dock.
Pros:
- 11 programmable buttons with 7 side buttons for macros, skills, and shortcuts.
- Tri-mode connectivity supports 2.4GHz wireless, Bluetooth, and wired use.
- PAW3311 sensor offers up to 12,000 DPI with 6 sensitivity levels.
- Includes an RGB charging dock and a rechargeable battery for easy top-ups.
Cons:
- The listed button quantity is 7 in the details, so the control layout may be a little confusing at a glance.
- It uses a 12,000 DPI sensor, which is lower than some premium gaming mice.
For buyers who want a practical MMO mouse with side buttons and broad connection options, this model covers the essentials well. It focuses on features that matter for multitasking and shortcut-heavy play rather than premium-spec extremes.
How We Picked the Best Gaming Mouse with Side Buttons
We focused on models with enough programmable side buttons to matter in real play, along with reliable sensors, good ergonomics, and button placement that is easy to learn in-game. We also favored mice with solid software support, dependable wireless performance where applicable, and features that fit the needs of players who use a Gaming Mouse with Side Buttons for macros and hotkeys.
Quick Comparison
Broadly, the strongest MMO-focused picks offer the most side inputs and the best macro flexibility. Balanced all-around choices usually have fewer buttons but better shape versatility for different genres. Wired models can still be the best value when you want low maintenance and consistent latency, while wireless picks are ideal if you prefer a cleaner desk and more freedom of movement.
Key Buying Factors for a Gaming Mouse with Side Buttons
Button Count and Placement
More buttons are not always better if they are hard to reach. Look for a layout that matches how you play. MMO and productivity users may benefit from a dense thumb grid, while MOBA and hybrid players may prefer a simpler cluster that is easier to hit accurately.
Sensor and Tracking
High DPI numbers matter less than accurate tracking and stable performance. A good Gaming Mouse with Side Buttons should feel precise at both low and high sensitivity settings, especially if you switch between fast camera movement and fine aiming.
Ergonomics and Grip Style
Shape is a major deciding factor. Larger MMO mice can be excellent for palm grip and long sessions, but may feel bulky for claw or fingertip users. If comfort is a priority, check the mouse dimensions, weight, and whether the thumb buttons are positioned for your hand size.
Wired Vs. Wireless
Wired mice usually offer the simplest setup and no charging concerns. Wireless models are better if you value freedom of movement or travel often. Modern wireless options can be excellent for gaming, so battery life and charging method should be part of the decision.
Software and Macro Support
If you plan to remap side buttons, verify that the mouse software is stable and easy to use. Good macro tools, onboard memory, and per-profile customization make a big difference for MMO rotations, editing shortcuts, and multitasking.
Who Should Buy Which Gaming Mouse with Side Buttons?
Choose a high-button MMO model if you want maximum control for spells, abilities, and shortcuts. Pick a more balanced wireless or ergonomic option if you play multiple genres and want a mouse that still feels natural outside of gaming. Budget buyers should prioritize a dependable sensor and comfortable shape over the largest button count, while power users should look for the best mix of programmability, software, and hand fit.